Osilodrostat phosphate


Entry
D11062                      Drug                                   
Name
Osilodrostat phosphate (JAN/USAN);
Isturisa (TN)
Product
ISTURISA (Recordati Rare Diseases)
Formula
C13H10FN3. H3PO4
Exact mass
325.0628
Mol weight
325.2322
Structure
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02924  UGT substrate
Remark
Therapeutic category: 2499
ATC code: H02CA02
Chemical structure group: DG02839
Product (DG02839): D11062<JP/US>
Efficacy
Antihypertensive, Steroid 11-beta-hydroxylase inhibitor
  Disease
Cushing's disease [DS:H01431]
Comment
Treatment of Cushing's syndrome
Target
CYP11B2 [HSA:1585] [KO:K07433]
  Pathway
hsa00140  Steroid hormone biosynthesis
hsa04925  Aldosterone synthesis and secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565], UGT [KO:K00699]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H02 CORTICOSTEROIDS FOR SYSTEMIC USE
   H02C ANTIADRENAL PREPARATIONS
    H02CA Anticorticosteroids
     H02CA02 Osilodrostat
      D11062  Osilodrostat phosphate (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D11062  Osilodrostat phosphate (JAN/USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   DG02839  Osilodrostat
    D11062  Osilodrostat phosphate
  DG01644  CYP2D6 substrate
   DG02839  Osilodrostat
    D11062  Osilodrostat phosphate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG02839  Osilodrostat
     D11062  Osilodrostat phosphate
  DG02924  UGT substrate
   DG02839  Osilodrostat
    D11062  Osilodrostat phosphate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Cytochrome P450
    CYP11B2
     D11062  Osilodrostat phosphate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11062
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11062
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11062
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11062
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11062
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   DG02839  Osilodrostat
  DG01644  CYP2D6 substrate
   DG02839  Osilodrostat
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG02839  Osilodrostat
  DG02924  UGT substrate
   DG02839  Osilodrostat
Other DBs
CAS: 1315449-72-9
PubChem: 405226449
KCF data

ATOM        22
            1   C8x C    17.1471  -14.6975
            2   C8y C    17.1471  -16.0973
            3   C8y C    18.3369  -16.7972
            4   C8x C    19.5267  -16.0973
            5   C8x C    19.5267  -14.6975
            6   C8y C    18.3369  -13.9976
            7   C3b C    18.3369  -12.5979
            8   N3a N    18.3369  -11.1981
            9   X   F    15.9573  -16.7972
            10  C1y C    18.3369  -18.1969
            11  C1x C    17.2171  -18.9668
            12  C1x C    17.6370  -20.3666
            13  C8y C    19.0368  -20.3666
            14  N4y N    19.4567  -18.9668
            15  C8x C    20.1566  -21.1364
            16  N5x N    21.3464  -20.3666
            17  C8x C    20.8565  -18.9668
            18  P1b P    24.0800  -16.8000
            19  O1c O    22.6800  -16.8000
            20  O1c O    25.4800  -16.8000
            21  O1c O    24.0800  -18.2000
            22  O1c O    24.0800  -15.4000
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     7   8 3
            9     2   9 1
            10   10   3 1 #Down
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   14  17 1
            20   18  19 1
            21   18  20 1
            22   18  21 1
            23   18  22 2