| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Glasdegib maleate (JAN); Daurismo (TN) | ||||||
| Product | DAURISMO (Pfizer Laboratories Div Pfizer) | ||||||
| Formula | C21H22N6O. C4H4O4 | ||||||
| Exact mass | 490.1965 | ||||||
| Mol weight | 490.5111 | ||||||
| Structure |  | ||||||
| Simcomp | |||||||
| Class | Antineoplastic DG01566 Hedgehog signaling inhibitor | ||||||
| Remark |
| ||||||
| Efficacy | Antineoplastic, Smoothened receptor antagonist | ||||||
| Disease | Acute myeloid leukemia [DS:H00003] | ||||||
| Target | SMO [HSA:6608] [KO:K06226] | ||||||
| Pathway |
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| Interaction | |||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS L01 ANTINEOPLASTIC AGENTS L01X OTHER ANTINEOPLASTIC AGENTS L01XJ Hedgehog pathway inhibitors L01XJ03 Glasdegib D11107 Glasdegib maleate (JAN) <US> USP drug classification [BR:br08302] Antineoplastics Molecular Target Inhibitors Glasdegib D11107 Glasdegib maleate (JAN) Drug groups [BR:br08330] Antineoplastic DG01566 Hedgehog signaling inhibitor DG02912 Glasdegib D11107 Glasdegib maleate Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Frizzled / Smoothened family Smoothened SMO D11107 Glasdegib maleate (JAN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D11107 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D11107 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11107 Drug groups [BR:br08330] Antineoplastic DG01566 Hedgehog signaling inhibitor DG02912 Glasdegib | ||||||
| Other DBs |
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| KCF data | ATOM 36 1 C1y C 15.6185 -15.0605 2 C8x C 9.8315 -14.3633 3 C8x C 9.8315 -15.7577 4 C8x C 11.0168 -16.4549 5 C8y C 12.2718 -15.7577 6 C8y C 12.2718 -14.3633 7 C8x C 11.0168 -13.5963 8 N4x N 13.6663 -16.1761 9 C8y C 14.4333 -15.0605 10 N5x N 13.6663 -13.8752 11 C1x C 16.3158 -16.2458 12 C1y C 17.7102 -16.2458 13 C1x C 18.4075 -15.0605 14 C1x C 17.7102 -13.8055 15 N1y N 16.3158 -13.8055 16 N1b N 18.4075 -17.5008 17 C5a C 19.8019 -17.5008 18 O5a O 20.4992 -16.2458 19 N1b N 20.4992 -18.6861 20 C8y C 21.8936 -18.6861 21 C8x C 22.6606 -19.8714 22 C8x C 24.0550 -19.8714 23 C8y C 24.7523 -18.6861 24 C8x C 24.0550 -17.5008 25 C8x C 22.6606 -17.5008 26 C3b C 26.1467 -18.6861 27 N3a N 27.5412 -18.6861 28 C1a C 15.6185 -12.5504 29 C2b C 25.1300 -12.5300 30 C2b C 26.5300 -12.5300 31 C6a C 24.4300 -13.7424 32 C6a C 27.2300 -13.7424 33 O6a O 28.6298 -13.7424 34 O6a O 26.5396 -14.9379 35 O6a O 23.0302 -13.7424 36 O6a O 25.1204 -14.9379 BOND 38 1 2 3 2 2 3 4 1 3 4 5 2 4 5 6 1 5 6 7 2 6 2 7 1 7 5 8 1 8 8 9 1 9 9 10 2 10 6 10 1 11 1 9 1 #Down 12 1 11 1 13 11 12 1 14 12 13 1 15 13 14 1 16 14 15 1 17 1 15 1 18 12 16 1 #Up 19 16 17 1 20 17 18 2 21 17 19 1 22 19 20 1 23 20 21 2 24 21 22 1 25 22 23 2 26 23 24 1 27 24 25 2 28 20 25 1 29 23 26 1 30 26 27 3 31 15 28 1 32 29 30 2 33 29 31 1 34 30 32 1 35 32 33 2 36 32 34 1 37 31 35 1 38 31 36 2 |