Entry

D11120                      Drug

Name

Emapalumab (USAN/INN);
Emapalumab (genetical recombination) (JAN);
Emapalumab-lzsg;
Gamifant (TN)

Product

GAMIFANT (Swedish Orphan Biovitrum AB (publ))

Formula

C6430H9898N1718O2038S46

Exact mass

145261.0846

Mol weight

145350.6689

Sequence

(Heavy chain)
EVQLLESGGG LVQPGGSLRL SCAASGFTFS SYAMSWVRQA PGKGLEWVSA ISGSGGSTYY
ADSVKGRFTI SRDNSKNTLY LQMNSLRAED TAVYYCAKDG SSGWYVPHWF DPWGQGTLVT
VSSASTKGPS VFPLAPSSKS TSGGTAALGC LVKDYFPEPV TVSWNSGALT SGVHTFPAVL
QSSGLYSLSS VVTVPSSSLG TQTYICNVNH KPSNTKVDKR VEPKSCDKTH TCPPCPAPEL
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE
QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS
REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK
SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
(Light chain)
NFMLTQPHSV SESPGKTVTI SCTRSSGSIA SNYVQWYQQR PGSSPTTVIY EDNQRPSGVP
DRFSGSIDSS SNSASLTISG LKTEDEADYY CQSYDGSNRW MFGGGTKLTV LGQPKAAPSV
TLFPPSSEEL QANKATLVCL ISDFYPGAVT VAWKADSSPV KAGVETTTPS KQSNNKYAAS
SYLSLTPEQW KSHRSYSCQV THEGSTVEKT VAPTECS
(Disulfide bridge: H22-H96, H150-H206, H226-L216, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'150-H'206, H'226-L'216, H'267-H'327, H'373-H'431, L22-L91, L139-L198, L'22-L'91, L'139-L'198)

Type

Peptide

Remark

ATC code:

L04AA39

Product:

D11120<US>

Efficacy

Antineoplastic, Anti-INF-gamma antibody

Disease

Primary hemophagocytic lymphohistiocytosis [DS:H00109]

Comment

Monoclonal antibody
Treatment of hemophagocytic lymphohistiocytosis (HLH) and other conditions

Target

IFNG [HSA:3458] [KO:K04687]

Interaction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AA Selective immunosuppressants
     L04AA39 Emapalumab
      D11120  Emapalumab (USAN/INN) <US>
USP drug classification [BR:br08302]
Immunological Agents
  Immunological Agents, Other
   Immunological Agents, Miscellaneous
    Emapalumab
     D11120  Emapalumab (USAN/INN)
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Cytokines
   Interferons
    IFNG
     D11120  Emapalumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D11120
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11120

Other DBs

CAS:	1709815-23-5

PubChem:

376219044