Flortaucipir F 18


Entry
D11210                      Drug                                   
Name
Flortaucipir F 18 (USAN);
Flortaucipir (18F) (INN);
Tauvid (TN)
Product
TAUVID (Eli Lilly and Company)
Formula
C16H10FN3
Exact mass
262.0884
Mol weight
263.2691
Structure
Remark
Product: D11210<US>
Efficacy
Diagnostic aid
Comment
Imaging to distinctive characteristic of Alzheimer's disease in the brain called tau pathology.
Target
MAPT (TAU) [HSA:4137] [KO:K04380]
  Pathway
hsa04010  MAPK signaling pathway
hsa05010  Alzheimer disease
Brite
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    MAPT (TAU)
     D11210  Flortaucipir F 18 (USAN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11210
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11210
Other DBs
CAS: 1522051-90-6
PubChem: 384585188
KCF data

ATOM        20
            1   C8x C    22.1900   -9.8000
            2   C8y C    22.1900  -11.2000
            3   C8x C    23.4024  -11.9000
            4   N5x N    24.6149  -11.2000
            5   C8y C    24.6149   -9.8000
            6   C8x C    23.4024   -9.1000
            7   C8y C    20.9776  -11.9000
            8   C8x C    19.7821  -11.2096
            9   C8x C    18.5696  -11.9095
            10  C8y C    18.5694  -13.3095
            11  C8y C    19.7649  -13.9999
            12  C8x C    20.9774  -13.3000
            13  C8y C    17.5434  -14.2331
            14  C8y C    18.1047  -15.4944
            15  N4x N    19.4777  -15.3502
            16  C8x C    16.1510  -14.0866
            17  N5x N    15.3280  -15.2191
            18  C8x C    15.8894  -16.4804
            19  C8x C    17.2817  -16.6269
            20  X   F    25.8460   -9.0890
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13    7  12 1
            14   10  13 1
            15   13  14 1
            16   14  15 1
            17   11  15 1
            18   13  16 2
            19   16  17 1
            20   17  18 2
            21   18  19 1
            22   14  19 2
            23    5  20 1