Entry

D11303                      Drug

Name

Eptinezumab (USAN);
Eptinezumab (genetical recombination) (JAN);
Eptinezumab-jjmr;
Vyepti (TN)

Product

VYEPTI (Lundbeck Pharmaceuticals LLC)

Formula

C6352H9838N1694O1992S46

Exact mass

143192.7752

Mol weight

143281.2247

Sequence

(Heavy chain)
EVQLVESGGG LVQPGGSLRL SCAVSGIDLS GYYMNWVRQA PGKGLEWVGV IGINGATYYA
SWAKGRFTIS RDNSKTTVYL QMNSLRAEDT AVYFCARGDI WGQGTLVTVS SASTKGPSVF
PLAPSSKSTS GGTAALGCLV KDYFPEPVTV SWNSGALTSG VHTFPAVLQS SGLYSLSSVV
TVPSSSLGTQ TYICNVNHKP SNTKVDARVE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK
PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY ASTYRVVSVL
TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRE EMTKNQVSLT
CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS
VMHEALHNHY TQKSLSLSPG K
(Light chain)
QVLTQSPSSL SASVGDRVTI NCQASQSVYH NTYLAWYQQK PGKVPKQLIY DASTLASGVP
SRFSGSGSGT DFTLTISSLQ PEDVATYYCL GSYDCTNGDC FVFGGGTKVE IKRTVAAPSV
FIFPPSDEQL KSGTASVVCL LNNFYPREAK VQWKVDNALQ SGNSQESVTE QDSKDSTYSL
SSTLTLSKAD YEKHKVYACE VTHQGLSSPV TKSFNRGEC
(Disulfide bridge: H22-H95, H138-H194, H214-L219, H220-H'220, H223-H'223, H255-H315, H361-H419, H'22-H'95, H'138-H'194, H'214-L'219, H'255-H'315, H'361-H'419, L22-L89, L139-L199, L'22-L'89, L'139-L'199)

Type

Peptide

Remark

ATC code:

N02CD05

Product:

D11303<US>

Efficacy

Antimigraine, Anti-calcitonin gene-related peptide (GCRP) antibody

Comment

Monoclonal antibody
Prevention of migraine

Target

CALCA (CGRP) [HSA:796] [KO:K12332]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04270

Vascular smooth muscle contraction

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CD Calcitonin gene-related peptide (CGRP) antagonists
     N02CD05 Eptinezumab
      D11303  Eptinezumab (USAN) <US>
USP drug classification [BR:br08302]
Antimigraine Agents
  Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist
   Eptinezumab
    D11303  Eptinezumab (USAN)
Target-based classification of drugs [BR:br08310]
Not elsewhere classified
  Organismal systems
   Circulatory system
    CALCA (CGRP)
     D11303  Eptinezumab (USAN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D11303
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D11303
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11303

Other DBs

CAS:	1644539-04-7

PubChem:

384585281