Voxelotor


Entry
D11330                      Drug                                   
Name
Voxelotor (USAN);
Oxbryta (TN)
Product
OXBRYTA (Global Blood Therapeutics)
Formula
C19H19N3O3
Exact mass
337.1426
Mol weight
337.3725
Structure
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: B06AX03
Product: D11330<US>
Efficacy
Anti-anemic, Hemoglobin S polymerization inhibitor
  Disease
Sickle cell disease [DS:H00229]
Comment
Treatment of sickle cell disease
Hemoglobin oxygen-affinity modulator
Metabolism
Enzyme: CYP3A4 [HSA:1576]; CYP2C19 [HSA:1557], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B06 OTHER HEMATOLOGICAL AGENTS
   B06A OTHER HEMATOLOGICAL AGENTS
    B06AX Other hematological agents
     B06AX03 Voxelotor
      D11330  Voxelotor (USAN) <US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Voxelotor
   D11330  Voxelotor (USAN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D11330  Voxelotor
  DG01642  CYP2C9 substrate
   D11330  Voxelotor
  DG01639  CYP2C19 substrate
   D11330  Voxelotor
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11330  Voxelotor
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11330
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11330
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11330
Other DBs
CAS: 1446321-46-5
PubChem: 384585308
KCF data

ATOM        25
            1   C8x C    10.6400  -17.5700
            2   C8x C    10.6400  -18.9700
            3   C8x C    11.8300  -19.6700
            4   C8y C    13.0900  -18.9700
            5   C8y C    13.0900  -17.5700
            6   N5x N    11.8300  -16.8700
            7   C1b C    14.2800  -19.6700
            8   O2a O    15.4700  -18.9700
            9   C8y C    16.6600  -19.6700
            10  C8x C    16.6600  -21.0700
            11  C8x C    17.9200  -21.7700
            12  C8x C    19.1100  -21.0700
            13  C8y C    19.1100  -19.6700
            14  C8y C    17.9200  -18.9700
            15  C4a C    17.9200  -17.5700
            16  O4a O    19.1100  -16.8700
            17  O1a O    20.3000  -18.9700
            18  C8y C    14.2800  -16.8700
            19  C8x C    15.6100  -17.2900
            20  C8x C    16.4500  -16.1700
            21  N5x N    15.6100  -15.0500
            22  N4y N    14.2800  -15.4700
            23  C1c C    13.0900  -14.7700
            24  C1a C    11.9000  -15.4700
            25  C1a C    13.0900  -13.3700
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   14  15 1
            17   15  16 2
            18   13  17 1
            19    5  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   18  22 1
            25   23  22 1
            26   23  24 1
            27   23  25 1