| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Ripretinib (USAN); Qinlock (TN) | ||||||
| Product | QINLOCK (Deciphera Pharmaceuticals) | ||||||
| Formula | C24H21BrFN5O2 | ||||||
| Exact mass | 509.0863 | ||||||
| Mol weight | 510.3582 | ||||||
| Structure |  | ||||||
| Class | Antineoplastic DG01918 Tyrosine kinase inhibitor DG01917 Receptor tyrosine kinase inhibitor | ||||||
| Remark |
| ||||||
| Efficacy | Antineoplastic, Receptor tyrosine kinase inhibitor | ||||||
| Disease | Gastrotintestinal stromal tumor [DS:H01591] | ||||||
| Target | KIT (CD117) [HSA:3815] [KO:K05091] PDGFRA [HSA:5156] [KO:K04363] | ||||||
| Pathway |
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| Interaction | |||||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS L01 ANTINEOPLASTIC AGENTS L01E PROTEIN KINASE INHIBITORS L01EX Other protein kinase inhibitors L01EX19 Ripretinib D11353 Ripretinib (USAN) <US> USP drug classification [BR:br08302] Antineoplastics Molecular Target Inhibitors Ripretinib D11353 Ripretinib (USAN) Drug groups [BR:br08330] Antineoplastic DG01918 Tyrosine kinase inhibitor DG01917 Receptor tyrosine kinase inhibitor D11353 Ripretinib Target-based classification of drugs [BR:br08310] Protein kinases Receptor tyrosine kinases (RTK) PDGFR family PDGFRA D11353 Ripretinib (USAN) <US> KIT (CD117) D11353 Ripretinib (USAN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D11353 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D11353 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11353 | ||||||
| Other DBs |
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| KCF data | ATOM 33 1 C8x C 22.9600 -15.9600 2 C8x C 22.9600 -17.3600 3 C8x C 21.7700 -18.0600 4 C8y C 20.5100 -17.3600 5 C8x C 20.5100 -15.9600 6 C8x C 21.7700 -15.2600 7 N1b N 19.3200 -18.0600 8 C5a C 18.1300 -17.3600 9 N1b N 16.9400 -18.0600 10 O5a O 18.1300 -15.9600 11 C8y C 15.7500 -17.3600 12 C8x C 14.5600 -18.0600 13 C8y C 13.3000 -17.3600 14 C8y C 13.3000 -15.9600 15 C8x C 14.4900 -15.2600 16 C8y C 15.7500 -15.9600 17 C8y C 12.1100 -18.0600 18 C8y C 12.1100 -19.4600 19 N4y N 10.8500 -20.1600 20 C8y C 9.6600 -19.4600 21 C8y C 9.6600 -18.0600 22 C8x C 10.8500 -17.3600 23 C8x C 8.4700 -20.1600 24 C8y C 7.2100 -19.4600 25 N5x N 7.2100 -18.0600 26 C8x C 8.4700 -17.3600 27 N1b N 6.0200 -20.1600 28 C1a C 4.8300 -19.4600 29 C1b C 10.8500 -21.5600 30 C1a C 12.0400 -22.2600 31 O5x O 13.3000 -20.1600 32 X Br 12.1100 -15.2600 33 X F 16.9400 -15.2600 BOND 36 1 1 2 2 2 2 3 1 3 3 4 2 4 4 5 1 5 5 6 2 6 1 6 1 7 4 7 1 8 7 8 1 9 8 9 1 10 8 10 2 11 9 11 1 12 11 12 2 13 12 13 1 14 13 14 2 15 14 15 1 16 15 16 2 17 11 16 1 18 13 17 1 19 17 18 1 20 18 19 1 21 19 20 1 22 20 21 1 23 21 22 1 24 17 22 2 25 20 23 2 26 23 24 1 27 24 25 2 28 25 26 1 29 21 26 2 30 24 27 1 31 27 28 1 32 19 29 1 33 29 30 1 34 18 31 2 35 14 32 1 36 16 33 1 |