Entry

D11486                      Drug

Name

Lonapegsomatropin (USAN/INN);
Lonapegsomatropin-tcgd;
Skytrofa (TN)

Product

SKYTROFA (Ascendis Pharma Endocrinology)

Sequence

FPTIPLSRLF DNAMLRAHRL HQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEG
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFRKDM DKVETFLRIV
QCRSVEGSCG F
(Disulfide bridge: 53-165, 182-189)

Type

Peptide

Class

Hormonal agent
DG03170 Growth hormone receptor agonist

Remark

Product:

D11486<US>

Efficacy

Growth hormone (GH) receptor agonist

Disease

Growth hormone deficiency [DS:H00254]

Comment

Treatment of growth hormone deficiency

Target

GHR [HSA:2690] [KO:K05080]

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04080

Neuroactive ligand-receptor interaction

hsa04151

PI3K-Akt signaling pathway

hsa04630

JAK-STAT signaling pathway

Brite

USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Pituitary)
  Lonapegsomatropin
   D11486  Lonapegsomatropin (USAN/INN)
Drug groups [BR:br08330]
Hormonal agent
  DG03170  Growth hormone receptor agonist
   D11486  Lonapegsomatropin
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Cytokine receptors
   CSF and other factor receptors
    GHR
     D11486  Lonapegsomatropin (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D11486
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11486

Other DBs

CAS:	1934255-39-6

PubChem:

384585462