Trastuzumab deruxtecan


Entry
D11529                      Drug                                   
Name
Trastuzumab deruxtecan (USAN/INN);
Trastuzumab deruxtecan (genetical recombination) (JAN);
Fam-trastuzumab deruxtecan-nxki;
Enhertu (TN)
Product
ENHERTU (Daiichi Sankyo)
Formula
C6460H9972N1724O2014S44. (C52H57FN9O13)8
Exact mass
153607.1079
Mol weight
153701.9811
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03158  HER2 inhibitor
Remark
Therapeutic category: 4291
ATC code: L01FD04
Product: D11529<JP/US>
Efficacy
Antineoplastic
  Disease
Breast cancer (HER2 positive) [DS:H00031]
Comment
Antibody-drug conjugate
Target
ERBB2* (HER2, CD340) [HSA_VAR:2064v1] [HSA:2064] [KO:K05083]
TOP1 [HSA:7150] [KO:K03163]
  Pathway
hsa01521  EGFR tyrosine kinase inhibitor resistance
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FD HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
     L01FD04 Trastuzumab deruxtecan
      D11529  Trastuzumab deruxtecan (USAN/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D11529  Trastuzumab deruxtecan (USAN/INN); Trastuzumab deruxtecan (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03158  HER2 inhibitor
     D11529  Trastuzumab deruxtecan
Drug classes [BR:br08332]
 Antineoplastic
  DG03158  HER2 inhibitor
   D11529  Trastuzumab deruxtecan
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    ERBB2* (HER2, CD340) [HSA_VAR:2064v1]
     D11529  Trastuzumab deruxtecan (USAN/INN) <JP/US>
 Enzymes
  Isomerases (EC5)
   DNA topoisomerase
    TOP1
     D11529  Trastuzumab deruxtecan (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11529
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D11529
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D11529
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11529
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D11529
Other DBs
CAS: 1826843-81-5
PubChem: 384585505