Oxycodone and ibuprofen


Entry
D11573            Mixture   Drug                                   
Name
Oxycodone and ibuprofen
Component
(Oxycodone hydrochloride [DR:D00847] | Oxycodone [DR:D05312] | Oxycodone hydrochloride hydrate [DR:D05462]), (Ibuprofen [DR:D00126] | Ibuprofen piconol [DR:D01122] | Ibuprofen aluminum [DR:D04490] | Ibuprofen lysine [DR:D06606] | Ibuprofen sodium [DR:D08059] | Ibuprofen sodium [DR:D09760])
Class
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N02AJ19
Efficacy
Analgesic
Comment
Oxycodone is a substrate of CYP3A4 and CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2A6 [HSA:1548]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AJ Opioids in combination with non-opioid analgesics
     N02AJ19 Oxycodone and ibupurofen
      D11573  Oxycodone and ibuprofen
USP drug classification [BR:br08302]
 Analgesics
  Analgesics Combinations
   Oxycodone Hydrochloride/ Ibuprofen
    D11573  Oxycodone and ibuprofen
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   D11573  Oxycodone and ibuprofen
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D11573  Oxycodone and ibuprofen
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D11573
Other DBs
PubChem: 384585548