| Entry |
| ||||||
|---|---|---|---|---|---|---|---|
| Name | Tirbanibulin (USAN/INN); Klisyri (TN) | ||||||
| Product | KLISYRI (Almirall) | ||||||
| Formula | C26H29N3O3 | ||||||
| Exact mass | 431.2209 | ||||||
| Mol weight | 431.5268 | ||||||
| Structure |  | ||||||
| Remark |
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| Efficacy | Antineoplastic, Tubulin polymerization inhibitor, Tyrosine kinase inhibitor | ||||||
| Disease | Actinic keratosis [DS:H02429] | ||||||
| Target | SRC [HSA:6714] [KO:K05704] TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375] | ||||||
| Pathway |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] D DERMATOLOGICALS D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE D06B CHEMOTHERAPEUTICS FOR TOPICAL USE D06BX Other chemotherapeutics D06BX03 Tirbanibulin D11691 Tirbanibulin (USAN/INN) <US> USP drug classification [BR:br08302] Dermatological Agents Dermatological Agents, Other Warts and Actinic Keratosis Agents Tirbanibulin D11691 Tirbanibulin (USAN/INN) Target-based classification of drugs [BR:br08310] Protein kinases Non-receptor tyrosine kinases SRC family SRC D11691 Tirbanibulin (USAN/INN) <US> Not elsewhere classified Cellular process Cytoskeleton TUBB D11691 Tirbanibulin (USAN/INN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D11691 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D11691 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11691 | ||||||
| Other DBs |
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| KCF data | ATOM 32 1 O2x O 25.2700 -16.3800 2 C1x C 25.2700 -17.7800 3 C1x C 24.0800 -18.4800 4 N1y N 22.8200 -17.7800 5 C1x C 22.8200 -16.3800 6 C1x C 24.0800 -15.6800 7 C1b C 21.6300 -18.4800 8 C1b C 20.4400 -17.7800 9 O2a O 19.2500 -18.4800 10 C8y C 18.0600 -17.7800 11 C8x C 16.8700 -18.4800 12 C8x C 15.6100 -17.7800 13 C8y C 15.6100 -16.3800 14 C8x C 16.8000 -15.6800 15 C8x C 18.0600 -16.3800 16 C8y C 14.4200 -15.6800 17 C8x C 13.2300 -16.3800 18 C8x C 11.9700 -15.6800 19 C8y C 11.9700 -14.2800 20 N5x N 13.1600 -13.5800 21 C8x C 14.4200 -14.2800 22 C1b C 10.7800 -13.5800 23 C5a C 9.5900 -14.2800 24 N1b N 8.4000 -13.5800 25 O5a O 9.5900 -15.6800 26 C1b C 7.2100 -14.2800 27 C8y C 6.0200 -13.5800 28 C8x C 4.8300 -14.2800 29 C8x C 3.5700 -13.5800 30 C8x C 3.5700 -12.1800 31 C8x C 4.7600 -11.4800 32 C8x C 6.0200 -12.1800 BOND 35 1 1 2 1 2 2 3 1 3 3 4 1 4 4 5 1 5 5 6 1 6 1 6 1 7 4 7 1 8 7 8 1 9 8 9 1 10 9 10 1 11 10 11 2 12 11 12 1 13 12 13 2 14 13 14 1 15 14 15 2 16 10 15 1 17 13 16 1 18 16 17 2 19 17 18 1 20 18 19 2 21 19 20 1 22 20 21 2 23 16 21 1 24 19 22 1 25 22 23 1 26 23 24 1 27 23 25 2 28 24 26 1 29 26 27 1 30 27 28 2 31 28 29 1 32 29 30 2 33 30 31 1 34 31 32 2 35 27 32 1 |