| Entry |
| ||||
|---|---|---|---|---|---|
| Name | Odevixibat (USAN); Bylvay (TN) | ||||
| Product | BYLVAY (Albireo Pharma) | ||||
| Formula | C37H48N4O8S2 | ||||
| Exact mass | 740.2914 | ||||
| Mol weight | 740.929 | ||||
| Structure |  | ||||
| Class | Transporter substrate DG01665 ABCB1 substrate | ||||
| Remark |
| ||||
| Efficacy | Hepatoprotectants, Bile acid transporter (ASBT/IBAT) inhibitor | ||||
| Disease | Progressive familial intrahepatic cholestasis [DS:H00624] | ||||
| Comment | Treatment of cholestatic liver disease Bylvay may not be effective in PFIC type 2 patients with ABCB11 variants resulting in non-functional or complete absence of bile salt export pump protein (BSEP-3). | ||||
| Target | SLC10A2 (ASBT, IBAT) [HSA:6555] [KO:K14342] | ||||
| Pathway |
| ||||
| Metabolism | Transporter: ABCB1 [HSA:5243] | ||||
| Interaction | |||||
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] A ALIMENTARY TRACT AND METABOLISM A05 BILE AND LIVER THERAPY A05A BILE THERAPY A05AX Other drugs for bile therapy A05AX05 Odevixibat D11716 Odevixibat (USAN) <US> Drug groups [BR:br08330] Transporter substrate DG01665 ABCB1 substrate D11716 Odevixibat Target-based classification of drugs [BR:br08310] Transporters Solute carrier family SLC10 SLC10A2 (ASBT, IBAT) D11716 Odevixibat (USAN) <US> New drug approvals in the USA [br08319.html] New molecular entities and new therapeutic biological products D11716 New drug approvals in Europe [br08329.html] European public assessment reports (EPAR) authorised medicine D11716 New drug approvals in the USA, Europe and Japan [br08328.html] Approval dates by FDA, EMA and PMDA D11716 Drug metabolizing enzymes and transporters [br08309.html] Drug transporters D11716 Pharmacogenomic biomarkers [br08341.html] Polymorphisms and mutations affecting drug response D11716 | ||||
| Other DBs |
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| KCF data | ATOM 51 1 C8y C 17.7284 -15.1357 2 S2x S 16.6073 -14.2248 3 N1x N 15.2759 -14.5751 4 C1z C 14.6452 -15.8365 5 C8y C 17.7284 -16.5372 6 C1x C 15.2759 -17.0978 7 N1y N 16.6073 -17.3781 8 C8x C 18.9897 -17.2379 9 C8y C 20.1810 -16.5372 10 C8y C 20.1810 -15.1357 11 C8x C 18.9897 -14.4350 12 O3c O 16.2569 -12.8934 13 O3c O 17.8686 -13.5241 14 C8y C 16.9576 -18.7795 15 C8x C 15.9065 -19.7605 16 C8x C 16.1868 -21.0919 17 C8x C 17.5182 -21.5124 18 C8x C 18.5693 -20.5313 19 C8x C 18.2890 -19.2000 20 C1b C 13.6642 -16.8175 21 C1b C 13.4540 -15.1357 22 C1b C 12.2627 -15.8365 23 C1b C 11.0715 -15.1357 24 C1a C 9.8803 -15.8365 25 C1b C 13.6642 -18.2189 26 S2a S 21.4423 -17.2379 27 C1a C 22.6335 -16.6073 28 O2a O 21.4423 -14.4350 29 C1b C 22.6335 -15.1357 30 C5a C 23.8248 -14.4350 31 N1b N 25.0160 -15.1357 32 O5a O 23.8248 -13.0335 33 C1c C 26.2072 -14.4350 34 C8y C 27.3985 -15.1357 35 C5a C 26.2072 -13.0335 36 C1b C 12.4495 -18.9203 37 N1b N 27.4047 -12.3418 38 O5a O 24.9685 -12.3184 39 C1c C 27.4049 -10.9204 40 C6a C 28.5912 -10.2354 41 C1b C 26.1664 -10.2049 42 C1a C 24.9576 -10.9025 43 O6a O 29.7736 -10.9179 44 O6a O 28.5914 -8.8204 45 C8x C 27.3870 -16.5199 46 C8x C 28.5936 -17.2300 47 C8y C 29.8118 -16.5401 48 C8x C 29.8233 -15.1559 49 C8x C 28.6167 -14.4458 50 O1a O 31.0156 -17.2484 51 C1a C 11.2363 -18.2199 BOND 54 1 3 4 1 2 1 5 1 3 4 6 1 4 2 3 1 5 5 7 1 6 1 2 1 7 6 7 1 8 5 8 2 9 8 9 1 10 9 10 2 11 10 11 1 12 1 11 2 13 2 12 2 14 2 13 2 15 7 14 1 16 14 15 2 17 15 16 1 18 16 17 2 19 17 18 1 20 18 19 2 21 14 19 1 22 4 20 1 23 4 21 1 24 21 22 1 25 22 23 1 26 23 24 1 27 20 25 1 28 9 26 1 29 26 27 1 30 10 28 1 31 28 29 1 32 29 30 1 33 30 31 1 34 30 32 2 35 31 33 1 36 33 34 1 37 33 35 1 #Up 38 25 36 1 39 35 37 1 40 35 38 2 41 39 37 1 #Up 42 39 40 1 43 39 41 1 44 41 42 1 45 40 43 1 46 40 44 2 47 34 45 2 48 45 46 1 49 46 47 2 50 47 48 1 51 48 49 2 52 34 49 1 53 47 50 1 54 36 51 1 |