Entry

D11753                      Drug

Name

Evinacumab (USAN/INN);
Evinacumab (genetical recombination) (JAN);
Evinacumab-dgnb;
Evkeeza (TN)

Product

EVKEEZA (Regeneron Pharmaceuticals)

Formula

C6480H9992N1716O2042S46

Exact mass

145991.7936

Mol weight

146081.9345

Sequence

(Heavy chain)
EVQLVESGGG VIQPGGSLRL SCAASGFTFD DYAMNWVRQG PGKGLEWVSA ISGDGGSTYY
ADSVKGRFTI SRDNSKNSLY LQMNSLRAED TAFFYCAKDL RNTIFGVVIP DAFDIWGQGT
MVTVSSASTK GPSVFPLAPC SRSTSESTAA LGCLVKDYFP EPVTVSWNSG ALTSGVHTFP
AVLQSSGLYS LSSVVTVPSS SLGTKTYTCN VDHKPSNTKV DKRVESKYGP PCPPCPAPEF
LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSQEDPEVQ FNWYVDGVEV HNAKTKPREE
QFNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKGLPSSIEK TISKAKGQPR EPQVYTLPPS
QEEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSRLTVDK
SRWQEGNVFS CSVMHEALHN HYTQKSLSLS LGK
(Light chain)
DIQMTQSPST LSASVGDRVT ITCRASQSIR SWLAWYQQKP GKAPKLLIYK ASSLESGVPS
RFSGSGSGTE FTLTISSLQP DDFATYYCQQ YNSYSYTFGQ GTKLEIKRTV AAPSVFIFPP
SDEQLKSGTA SVVCLLNNFY PREAKVQWKV DNALQSGNSQ ESVTEQDSKD STYSLSSTLT
LSKADYEKHK VYACEVTHQG LSSPVTKSFN RGEC
(Disulfide bridge: H22-H96, H140-L214, H153-H209, H232-H'232, H235-H'235, H267-H327, H373-H431, H'22-H'96, H'140-L'214, H'153-H'209, H'267-H'327, H'373-H'431, L23-L88, L134-L194, L'23-L'88, L'134-L'194)

Type

Peptide

Remark

ATC code:

C10AX17

Product:

D11753<US>

Efficacy

Antihyperlipidemic, Anti-angiopietin like 3

Disease

Homozygous familial hypercholesterolemia [DS:H00155]

Comment

Monoclonal antibody
Treatment of dyslipidemia

Target

ANGPTL3 [HSA:27329] [KO:K22288]

Pathway

hsa04979

Cholesterol metabolism

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AX Other lipid modifying agents
     C10AX17 Evinacumab
      D11753  Evinacumab (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Cytokines
   Growth factors (RTK-binding)
    ANGPTL3
     D11753  Evinacumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D11753
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
  D11753
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11753

Other DBs

CAS:	1446419-85-7

PubChem:

405226619