Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01E PROTEIN KINASE INHIBITORS
L01EJ Janus-associated kinase (JAK) inhibitors
L01EJ03 Pacritinib
D11768 Pacritinib (USAN/INN) <US>
Drug groups [BR:br08330]
Antineoplastic
DG01918 Tyrosine kinase inhibitor
D11768 Pacritinib
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG02020 JAK inhibitor
D11768 Pacritinib
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D11768 Pacritinib
Drug classes [BR:br08332]
Immunological agent
DG02020 JAK inhibitor
D11768 Pacritinib
Antirheumatic agent
DG01985 Disease modifying anti-rheumatic drug (DMARD)
D11768 Pacritinib
Target-based classification of drugs [BR:br08310]
Protein kinases
Receptor tyrosine kinases (RTK)
PDGFR family
FLT3 (CD135)
D11768 Pacritinib (USAN/INN) <US>
Non-receptor tyrosine kinases
JAK family
JAK2
D11768 Pacritinib (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
D11768
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D11768
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D11768
Other DBs
CAS:
937272-79-2
PubChem:
405226634
PDB-CCD:
6T3[PDBj]
KCF data
ATOM 35
1 C8y C 21.4200 -14.0000
2 N4x N 21.4200 -15.4000
3 C8y C 22.6100 -16.1000
4 N5x N 23.8700 -15.4000
5 C8x C 23.8700 -14.0000
6 C8x C 22.6100 -13.3000
7 N2x N 22.6100 -17.5000
8 C8y C 20.2300 -13.3000
9 C8x C 20.2300 -11.9000
10 C8x C 18.9700 -11.2000
11 C8x C 17.7800 -11.9000
12 C8y C 17.7800 -13.3000
13 C8x C 18.9700 -14.0000
14 C1x C 16.5900 -14.0000
15 O2x O 15.4000 -13.3000
16 C1x C 14.2100 -14.0000
17 C2x C 14.2100 -15.4000
18 C2x C 15.4000 -16.1000
19 C1x C 15.4000 -17.5000
20 O2x O 16.5900 -18.2000
21 C1x C 17.7800 -17.5000
22 C8y C 18.9700 -18.2000
23 C8y C 18.9700 -19.6000
24 C8x C 20.1600 -20.3000
25 C8x C 21.4200 -19.6000
26 C8y C 21.4200 -18.2000
27 C8x C 20.1600 -17.5000
28 O2a O 17.7547 -20.2951
29 C1b C 16.5663 -19.6023
30 C1b C 15.3699 -20.2865
31 N1y N 14.1887 -19.5981
32 C1x C 14.2223 -18.2001
33 C1x C 12.9055 -17.7373
34 C1x C 12.0584 -18.8466
35 C1x C 12.8517 -19.9950
BOND 39
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 3 7 2
8 1 8 1
9 8 9 2
10 9 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 8 13 1
15 12 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 1
22 20 21 1
23 22 23 2
24 23 24 1
25 24 25 2
26 25 26 1
27 26 27 2
28 22 27 1
29 26 7 1
30 22 21 1
31 23 28 1
32 28 29 1
33 29 30 1
34 30 31 1
35 31 32 1
36 32 33 1
37 33 34 1
38 34 35 1
39 31 35 1