Entry

D11771                      Drug

Name

Tezepelumab (USAN/INN);
Tezepelumab (genetical recombination) (JAN);
Tezepelumab-ekko;
Tezspire (TN)

Product

TEZSPIRE (Amgen)

Formula

C6400H9844N1732O1992S52

Exact mass

144498.7714

Mol weight

144588.4306

Sequence

(Heavy chain)
QMQLVESGGG VVQPGRSLRL SCAASGFTFR TYGMHWVRQA PGKGLEWVAV IWYDGSNKHY
ADSVKGRFTI TRDNSKNTLN LQMNSLRAED TAVYYCARAP QWELVHEAFD IWGQGTMVTV
SSASTKGPSV FPLAPCSRST SESTAALGCL VKDYFPEPVT VSWNSGALTS GVHTFPAVLQ
SSGLYSLSSV VTVPSSNFGT QTYTCNVDHK PSNTKVDKTV ERKCCVECPP CPAPPVAGPS
VFLFPPKPKD TLMISRTPEV TCVVVDVSHE DPEVQFNWYV DGVEVHNAKT KPREEQFNST
FRVVSVLTVV HQDWLNGKEY KCKVSNKGLP APIEKTISKT KGQPREPQVY TLPPSREEMT
KNQVSLTCLV KGFYPSDIAV EWESNGQPEN NYKTTPPMLD SDGSFFLYSK LTVDKSRWQQ
GNVFSCSVMH EALHNHYTQK SLSLSPGK
(Light chain)
SYVLTQPPSV SVAPGQTARI TCGGNNLGSK SVHWYQQKPG QAPVLVVYDD SDRPSWIPER
FSGSNSGNTA TLTISRGEAG DEADYYCQVW DSSSDHVVFG GGTKLTVLGQ PKAAPSVTLF
PPSSEELQAN KATLVCLISD FYPGAVTVAW KADSSPVKAG VETTTPSKQS NNKYAASSYL
SLTPEQWKSH RSYSCQVTHE GSTVEKTVAP TECS
(Disulfide bridge: H22-H96, H136-L213, H149-H205, H224-H'224, H225-H'225, H228-H'228, H231-H'231, H262-H322, H368-H426, H'22-H'96, H'136-L'213, H'149-H'205, H'262-H'322, H'368-H'426, L22-L87, L136-L195, L'22-L'87, L'136-L'195)

Type

Peptide

Remark

ATC code:

R03DX11

Product:

D11771<US>

Efficacy

Anti-inflammatory, Anti thymic stromal lymphopoietin antibody

Disease

Asthma [DS:H00079]

Comment

Monoclonal antibody
Treatment of asthma and atopic dermatitis

Target

TSLP [HSA:85480] [KO:K05436]

Pathway

hsa04060

Cytokine-cytokine receptor interaction

hsa04630

JAK-STAT signaling pathway

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DX Other systemic drugs for obstructive airway diseases
     R03DX11 Tezepelumab
      D11771  Tezepelumab (USAN/INN) <US>
Target-based classification of drugs [BR:br08310]
Cytokines and receptors
  Cytokines
   CSF and other factors
    TSLP
     D11771  Tezepelumab (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D11771
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D11771

Other DBs

CAS:	1572943-04-4

PubChem:

405226637