Oteseconazole


Entry
D11785                      Drug                                   
Name
Oteseconazole (USAN/INN);
Vivijoa (TN)
Product
VIVJOA (Mycovia Pharmaceuticals)
Formula
C23H16F7N5O2
Exact mass
527.1192
Mol weight
527.3943
Structure
Class
Antifungal
 DG01523  Triazole antifungal
Remark
ATC code: J02AC06
Product: D11785<US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
  Disease
Vulvovaginal candidiasis [DS:H00363]
Target
sterol 14alpha-demethylase [KO:K05917]
  Pathway
ko00100  Steroid biosynthesis
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J02 ANTIMYCOTICS FOR SYSTEMIC USE
   J02A ANTIMYCOTICS FOR SYSTEMIC USE
    J02AC Triazole and tetrazole derivatives
     J02AC06 Oteseconazole
      D11785  Oteseconazole (USAN/INN) <US>
Drug groups [BR:br08330]
 Antifungal
  DG01523  Triazole antifungal
   D11785  Oteseconazole
Drug classes [BR:br08332]
 Antifungal
  DG01523  Triazole antifungal
   D11785  Oteseconazole
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Triazole
    D11785  Oteseconazole (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D11785
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D11785
Other DBs
CAS: 1340593-59-0
PubChem: 405226651
PDB-CCD: VT1[PDBj]
KCF data

ATOM        37
            1   C8y C    22.9826  -16.1026
            2   C1d C    22.9826  -18.4027
            3   C8y C    24.1675  -15.4056
            4   C8x C    21.8674  -15.4056
            5   C1d C    21.8674  -19.0996
            6   C1b C    24.1675  -19.0996
            7   C8x C    24.1675  -14.0116
            8   X   F    25.3524  -16.1026
            9   C8x C    21.8674  -14.0116
            10  C8y C    20.6826  -18.4027
            11  N4y N    25.3524  -18.4027
            12  C8y C    22.9826  -13.3146
            13  C8x C    25.4918  -17.0784
            14  N5x N    26.6070  -18.9602
            15  X   F    22.9826  -11.9206
            16  N5x N    26.8161  -16.7996
            17  N5x N    27.5131  -17.9148
            18  O1a O    22.9826  -19.7966
            19  N5x N    20.6826  -17.0087
            20  C8x C    19.4977  -16.3117
            21  C8y C    18.3128  -17.0087
            22  C8x C    18.3128  -18.4027
            23  C8x C    19.4977  -19.0996
            24  X   F    21.8674  -20.4936
            25  X   F    20.6826  -19.7966
            26  C8y C    17.1279  -16.3117
            27  C8x C    17.1279  -14.9177
            28  C8x C    15.9430  -14.2207
            29  C8y C    14.6884  -14.9177
            30  C8x C    14.6884  -16.3117
            31  C8x C    15.8733  -17.0087
            32  O2a O    13.5036  -14.2207
            33  C1b C    12.2490  -14.8480
            34  C1d C    11.0641  -14.1510
            35  X   F     9.8095  -13.4540
            36  X   F    11.7611  -12.9661
            37  X   F    10.3671  -15.3359
BOND        40
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 2
            16   14  17 2
            17    9  12 1
            18   16  17 1
            19    2  18 1 #Down
            20   10  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   10  23 1
            26    5  24 1
            27    5  25 1
            28   21  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   30  31 2
            34   26  31 1
            35   29  32 1
            36   32  33 1
            37   33  34 1
            38   34  35 1
            39   34  36 1
            40   34  37 1