Entry

D11858            Mixture   Drug

Name

Omeprazole magnesium, amoxicillin and rifabutin;
Talicia (TN)

Product

TALICIA (RedHill Biopharma)

Component

Omeprazole magnesium [DR:D05259], (Amoxicillin [DR:D00229] | Amoxicillin [DR:D07452]), Rifabutin [DR:D00424]

Class

Metabolizing enzyme substrate
DG01639  CYP2C19 substrate
DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
DG02853  CYP3A/CYP3A4 inducer

Remark

ATC code:

A02BD16

Product:

D11858<US>

Efficacy

Antibacterial

Disease

Helicobacter pylori infection [DS:H00320]

Comment

Rifabutin is a substrate and an inducer of CYP3A.
Omeprazole is a substrate and an inhibitor of CYP2C19, and a substrate of CYP3A4.

Metabolism

Enzyme: CYP3A [HSA:1576 1577 1551], CYP2C19 [HSA:1557]

Interaction

CYP induction: CYP3A [HSA:1576 1577 1551]
CYP inhibition: CYP2C19 [HSA:1557]

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BD Combinations for eradication of Helicobacter pylori
     A02BD16 Omeprazole, amoxicillin and rifabutin
      D11858  Omeprazole magnesium, amoxicillin and rifabutin <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Omeprazole Magnesium/ Amoxicillin/ Rifabutin
    D11858  Omeprazole magnesium, amoxicillin and rifabutin
Drug groups [BR:br08330]
Metabolizing enzyme substrate
  DG01639  CYP2C19 substrate
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
  DG01633  CYP3A/CYP3A4 substrate
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
Metabolizing enzyme inhibitor
  DG01933  CYP2C19 inhibitor
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
Metabolizing enzyme inducer
  DG02853  CYP3A/CYP3A4 inducer
   D11858  Omeprazole magnesium, amoxicillin and rifabutin
Antimicrobials [BR:br08307]
Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   Extended spectrum penicillin
    D11858  Omeprazole magnesium, amoxicillin and rifabutin <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D11858