COMPOUND: C07592


Entry
C07592                      Compound                               
Name
Colchicine
Formula
C22H25NO6
Exact mass
399.1682
Mol weight
399.437
Structure
Remark
Same as: D00570
Reaction
R08453
Pathway
map00950  Isoquinoline alkaloid biosynthesis
map01063  Biosynthesis of alkaloids derived from shikimate pathway
map01110  Biosynthesis of secondary metabolites
Enzyme
2.3.1.-
Brite
Phytochemical compounds [BR:br08003]
 Alkaloids
  Alkaloids derived from tyrosine
   Isoquinoline alkaloids
    C07592  Colchicine
Natural toxins [BR:br08009]
 Phytotoxins
  Alkaloids
   Isoquinoline alkaloids
    C07592  Colchicine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M04 ANTIGOUT PREPARATIONS
   M04A ANTIGOUT PREPARATIONS
    M04AC Preparations with no effect on uric acid metabolism
     M04AC01 Colchicine
      D00570  Colchicine (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antigout Agents
  Colchicine
   D00570  Colchicine (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   394  Gout preparations
    3941  Colchicines
     D00570  Colchicine (JP18/USP)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D00570  Colchicine
 Transporter substrate
  DG01665  ABCB1 substrate
   D00570  Colchicine
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D00570  Colchicine (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00570  Colchicine
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00570
 Drug transporters
  D00570
Other DBs
CAS: 64-86-8
PubChem: 9794
ChEBI: 27882
KNApSAcK: C00002327
PDB-CCD: LOC[PDBj]
3DMET: B02129
NIKKAJI: J9.267C
KCF data

ATOM        29
            1   C1x C    24.2478  -17.8139
            2   C8y C    23.4047  -16.6897
            3   C8y C    23.7560  -15.3547
            4   C1x C    25.6531  -17.8139
            5   C2y C    26.2855  -15.4249
            6   C1y C    26.5665  -16.7599
            7   C8y C    22.7021  -14.3710
            8   C8y C    21.3671  -14.7926
            9   C8y C    21.0158  -16.1276
            10  C8x C    22.0698  -17.1113
            11  O2a O    22.9832  -12.9657
            12  O2a O    20.3835  -13.8089
            13  O2a O    19.6808  -16.5491
            14  C2y C    25.0496  -14.7559
            15  C2x C    24.7816  -13.3324
            16  C2x C    25.7262  -12.3959
            17  C2y C    27.1396  -12.3717
            18  C5x C    27.9507  -13.5299
            19  C2x C    27.5622  -14.8377
            20  C1a C    18.6442  -15.6002
            21  C1a C    20.7471  -12.4515
            22  C1a C    24.3143  -12.5154
            23  O5x O    29.3587  -13.5119
            24  O2a O    27.7928  -11.1651
            25  C1a C    29.1664  -11.1969
            26  N1b N    27.9270  -17.1121
            27  C5a C    29.1062  -16.3876
            28  C1a C    30.3329  -17.0467
            29  O5a O    29.1333  -14.9844
BOND        31
            1     1   4 1
            2     2   3 1
            3     4   6 1
            4     1   2 1
            5     5   6 1
            6     3   7 2
            7     7   8 1
            8     8   9 2
            9     9  10 1
            10    2  10 2
            11    7  11 1
            12    8  12 1
            13    9  13 1
            14   16  17 2
            15   17  18 1
            16   15  16 1
            17    5  19 2
            18   14  15 2
            19   18  19 1
            20    3  14 1
            21   14   5 1
            22   13  20 1
            23   12  21 1
            24   11  22 1
            25   18  23 2
            26   17  24 1
            27   24  25 1
            28    6  26 1 #Up
            29   26  27 1
            30   27  28 1
            31   27  29 2

» Japanese version

  All links  
Pathway (3)   
   KEGG PATHWAY (3)   
Drug (1)   
   KEGG DRUG (1)   
Chemical substance (13)   
   PubChem (1)   
   ChEBI (1)   
   3DMET (1)   
   HMDB (1)   
   HSDB (1)   
   KNApSAcK (1)   
   MASSBANK (5)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Chemical reaction (1)   
   KEGG REACTION (1)   
All databases (18)   

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