Cytotoxicity of synthetic derivatives against breast cancer and multi-drug resistant breast cancer cell lines: a literature-based perspective study


Abstract

Cancer is the second most killer worldwide causing millions of people to lose their lives every year. In the case of women, breast cancer takes away the highest proportion of mortality rate than other cancers. Due to the mutation and resistance-building capacity of different breast cancer cell lines against conventional therapies, this death rate is on the verge of growth. New effective therapeutic compounds and treatment method is the best way to look out for in this critical time. For instance, new synthetic derivatives/ analogues synthesized from different compounds can be a ray of hope. Numerous synthetic compounds have been seen enhancing the apoptosis and autophagic pathway that directly exerts cytotoxicity towards different breast cancer cell lines. To cease the ever-growing resistance of multi-drug resistant cells against anti-breast cancer drugs (Doxorubicin, verapamil, tamoxifen) synthetic compounds may play a vital role by increasing effectivity, showing synergistic action. Many recent and previous studies have reported that synthetic derivatives hold potentials as an effective anti-breast cancer agent as they show great cytotoxicity towards cancer cells, thus can be used even vastly in the future in the field of breast cancer treatment. This review aims to identify the anti-breast cancer properties of several synthetic derivatives against different breast cancer and multi-drug-resistant breast cancer cell lines with their reported mechanism of action and effectivity.

Keywords: Breast cancer cell line; Cytotoxicity; MDR breast cancer cell line; Synthetic derivatives.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Mechanisms of breast cancer cell death. CYP cytochrome, ER endoplasmic reticulum, hAP-2γ human transcription factor activation protein-2 γ, PARP-1 poly [ADP-ribose] polymerase 1, RONS reactive oxygen and nitrogen species, VEGF vascular endothelial growth factor
Fig. 2
Fig. 2
Chemical structure of some synthetic derivatives that acting against different breast cancer cell lines
Fig. 3
Fig. 3
Mechanisms of chemotherapeutic drug resistance in cancer cells
Fig. 4
Fig. 4
Chemical structure of some synthetic derivatives that acting against multi-drug resistant MCF-7 cell-line
See this image and copyright information in PMC

Similar articles