234. Alfaprostol
Nomenclature
CAS number: 74176-31-1
(5Z)-7-[(1R,2S,3R,5S)-2-[(3S)-5-Cyclohexyl-3-hydroxy-1-pentynyl]-3,5-dihydroxycyclopentyl]-5-heptenoic
acid methyl ester; 18,19,20-trinor-17-cyclohexyl-13,14-didehydro-PGF2α methyl ester; Ro-22-9000; K-11941; Alfavet (Vetem); Gabbrostim (Vetem). C24H38O5; mol wt 406.56.
C 70.90%, H 9.42%, O 19.68%.
Description and references
Synthetic analog of prostaglandin F2α, q.v. Synthesis: C. Gandolfi et al., DE 2539116; eidem, US 4035415 (1976, 1977 both to Carlo Erba). Efficacy in bovine estrus synchronization: E. Schilling et al., Theriogenology 18, 413 (1982). Treatment of infertility in cows caused by persistent corpus luteum: G. Maffeo et al., Prostaglandins 25, 541 (1983). Efficacy in increasing calving rate in beef heifers and cows: E. R. doValle et al., J. Anim. Sci. 75, 897 (1997).
