299. Almagate

Nomenclature

CAS number: 66827-12-1
Aluminum magnesium carbonate hydroxide (AlMg3(CO3)(OH)7) hydrate (1:2); carbonic acid aluminum-magnesium complex; [carbonato(2)]heptahydroxy(aluminum)trimagnesium dihydrate; Almax (Almirall).
C2H14Al2Mg6O20.4H2O; mol wt 629.97.
C 3.81%, H 3.52%, Al 8.57%, Mg 23.15%, O 60.95%.
Al2Mg6(OH)14(CO3)2.4H2O.

Description and references

A crystalline hydrated aluminum-magnesium hydroxycarbonate. Prepn: R. G. W. Spickett et al., BE 873843; eidem, US 4447417 (1979, 1984 both to Anphar). Crystal structure: J. Moragues et al., Arzneim.-Forsch. 34, 1346 (1984). pH curves, acid consuming capacity: J. E. Beneyto et al., ibid. 1350. Effect of proteolytic enzymes, polypeptides: J. E. Beneyto, J. L. Fábregas, ibid. 1357. Serum levels of magnesium, aluminum not increased by high doses of almagate: J. Jauregui, J. Segura, ibid. 1364. Pharmacology: P. R. Beckett et al., ibid. 1367. Clinical trials: A. Suau et al., ibid. 1380.

Properties

Dehydrates at 510 K. USP acid neutralization capacity 28.3 mEq HCl/g.

Therapeutic Category

Antacid.

Keywords

Antacid