300. Alminoprofen

Nomenclature

CAS number: 39718-89-3
α-Methyl-4-[(2-methyl-2-propen-1-yl)amino]benzeneacetic acid; 2-(p-methylallylaminophenyl)propionic acid; EB-382; Minalfene (Bouchara).
C13H17NO2; mol wt 219.28.
C 71.21%, H 7.81%, N 6.39%, O 14.59%.

Description and references

Prepn: FR 2137211; E. Bouchera, US 3957850 (1971, 1976 both to Bouchera). Synthesis, pharmacology and toxicity data: B. Dumaitre et al., Eur. J. Med. Chem. 14, 207 (1979). Pharmacokinetic study: A. Premel-Cabic et al., Eur. J. Clin. Pharmacol. 18, 419 (1980).

Chemical structure

Properties

Crystals from cyclohexane, mp 107°. LD50 orally in mice: 2400 mg/kg (Dumaitre).

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Arylpropionic Acid Derivatives