313. Alprenolol

Nomenclature

CAS number: 13655-52-2
1-[(1-Methylethyl)amino]-3-[2-(2-propen-1-yl)phenoxy]-2-propanol; 1-(o-allylphenoxy)-3-(isopropylamino)-2-propanol; H-56/28.
C15H23NO2; mol wt 249.35.
C 72.25%, H 9.30%, N 5.62%, O 12.83%.

Description and references

β-Adrenergic blocker. Prepn: Brandstrom et al., Acta Pharm. Suec. 3, 303 (1966); NL 6605692 (1966 to AB Hassle), C.A. 66, 46214p (1967); NL 6612958 (1967 to ICI), C.A. 67, 99851w (1967). Pharmacology: Marmo, Clin. Ter. 56, 121-176 (1971). Series of articles on clinical effect in myocardial infarction: Acta Med. Scand. 1984, Suppl. 680, 1-64.

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 13707-88-5
Apllobal (Fujisawa); Aptine (Astra); Aptol Duriles (Astra); Gubernal (Novartis); Regletin (Teikoku Zoki); Yobir (Maruko).
C15H23NO2.HCl; mol wt 285.81.
C 63.04%, H 8.46%, N 4.90%, O 11.20%, Cl 12.40%.

Properties

Crystals from ethyl acetate, mp 107-109°. LD50 in mice, rats, rabbits (mg/kg): 278.0, 597.0, 337.3 orally (Marmo).

Therapeutic Category

Antihypertensive; antianginal; antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives