314. Alsactide

Nomenclature

CAS number: 34765-96-3
1-β-Alanine-17-[N-(4-aminobutyl)-l-lysinamide]-α1-17-corticotropin; 1-β-alanine-17-[l-2,6-diamino-N-(4-aminobutyl)hexanamide]-α1-17-corticotropin; [β-ala1,lys17]corticotropin-(1-17)-heptadecapeptide-4-amino-N-butylamide; [β-ala1,lys17]ACTH1-17-4-amino-N-butylamide; alisactide; HOE-433; Synchrodyn (Hoechst).
C99H155N29O21S; mol wt 2119.54.
C 56.10%, H 7.37%, N 19.16%, O 15.85%, S 1.51%.

Description and references

Short-chain ACTH analog. Synthesis: R. Geiger, H. G. Schroeder, DE 1954794; eidem, US 3749704 (1971, 1973, both to Hoechst); R. Geiger, Ann. 750, 165 (1971). Pharmacology: J. Sandow et al., Arch. Pharmacol. 297, Suppl. 2, R41 (1977). Dose dependent effects on cortisol and aldosterone plasma levels in man: A. Angeli et al., Horm. Metab. Res. 13, 24 (1981). Review of chronobiological activity: idem et al., Chronobiologica 14, 99-143 (1987).

Chemical structure

Derivative

Acetate.

Nomenclature

CAS number: 33194-27-3
C99H155N29O21S.xC2H4O2.

Properties

[α]D20 68.6° (c = 0.5 in 1% acetic acid).

Therapeutic Category

Diagnostic aid (adrenal function).

Keywords

Diagnostic Aid