426. N-(4-Aminobenzoyl)-l-glutamic acid
Nomenclature
CAS number: 4271-30-1
N-(p-Aminobenzoyl)glutamic acid; PABG. C12H14N2O5; mol wt 266.25.
C 54.13%, H 5.30%, N 10.52%, O 30.05%.
Description and references
Catabolite of folate. Prepn: J. Van der Scheer, K. Landsteiner, J. Immunol. 29, 371 (1935). Improved synthesis: A. P. Reddy, C. P. R. Reddy, Org. Prep. Proced. Int. 22, 117 (1990); P. Maunder et al., J. Chem. Soc. Perkin Trans. 1 1311 (1999). HPLC determn: B. A. Allen, R. A. Newman, J. Chromatogr. 190, 241 (1980); densitometric determn in folic acid tablets: J. Krzek, A. Kwiecien, J. Pharm. Biomed. Anal. 21, 451 (1999). Use as marker of folate degradation: J. McPartlin, J. Scott, Methods Enzymol. 281, 70 (1997); of turnover in pregnant women: J. F. Gregory, III et al., J. Nutr. 131, 1928 (2001).
