442. p-Aminohippuric Acid

Nomenclature

CAS number: 61-78-9
N-(4-Aminobenzoyl)glycine; N-(p-aminobenzoyl)aminoacetic acid; PAH.
C9H10N2O3; mol wt 194.19.
C 55.67%, H 5.19%, N 14.43%, O 24.72%.

Description and references

Prepn: J. B. Muenzen et al., J. Biol. Chem. 67, 469 (1926). Method to determine renal function: L. Schumann, P. W. Wüstenberg, Clin. Nephrol. 33, 35 (1990); R. A. Gabel et al., J. Pharmacol. Toxicol. Methods 36, 189 (1996).

Chemical structure

Properties

Short, irregular prisms from hot water, mp 199°. Soluble in alc, chloroform, benzene, acetone. Practically insol in cold water, ether, carbon tetrachloride.

Derivative

Sodium salt.

Nomenclature

CAS number: 94-16-6
Nephrotest (Biolog. Arbeitsgem.).
C9H9N2NaO3; mol wt 216.17.
C 50.01%, H 4.20%, N 12.96%, Na 10.64%, O 22.20%.

Properties

Soluble in water.

Therapeutic Category

Diagnostic aid (renal function).

Keywords

Diagnostic Aid