456. 6-Aminonicotinic Acid

Nomenclature

CAS number: 3167-49-5
6-Amino-3-pyridinecarboxylic acid; 6-amino-3-carboxypyridine.
C6H6N2O2; mol wt 138.12.
C 52.18%, H 4.38%, N 20.28%, O 23.17%.

Description and references

Prepd by heating 6-chloronicotinic acid with ammonia: Marckwald, Ber. 26, 2188 (1893); 27, 1319 (1894); Rth, Prauge, Ann. 467, 4 (1928); Johnson et al., J. Biol. Chem. 153, 37 (1944).

Chemical structure

Derivative

Dihydrate.

Properties

Crystals from dil acetic acid. Dec above 300° yielding 2-aminopyridine and CO2. Sparingly sol in most solvents.

Derivative

Potassium salt.
C6H5KN2O2; mol wt 176.21.
C 40.90%, H 2.86%, K 22.19%, N 15.90%, O 18.16%.

Properties

Crystals, freely sol in water, insol in alcohol.

Derivative

Hydrochloride.
C6H6N2O2.HCl; mol wt 174.58.
C 41.28%, H 4.04%, N 16.05%, O 18.33%, Cl 20.31%.

Properties

Needles, freely sol in water, slightly sol in alcohol.