457. 2-Amino-5-nitrothiazole

Nomenclature

CAS number: 121-66-4
5-Nitro-2-thiazolamine; Enheptin (Am. Cyanamid).
C3H3N3O2S; mol wt 145.14.
C 24.83%, H 2.08%, N 28.95%, O 22.05%, S 22.09%.

Description and references

Prepd by deacetylation of 2-acetamido-5-nitrothiazole: Hubbard; Steahly, US 2573641; US 2573656; US 2573657 (all 1951 to Monsanto).

Chemical structure

Properties

Greenish-yellow to orange-yellow fluffy powder, dec 202°. Slightly bitter taste. uv max (0.0005% in water): 386 nm (ε 0.540); min: 295 nm. Very sparingly soluble in water. To make a water soln, a 15% stock soln in propylene glycol should first be prepd. One gram dissolves in 150 g of 95% alcohol; in 250 g ether. Almost insol in chloroform. Sol in dilute mineral acids.

Therapeutic Category (Veterinary)

Antihistomonad in turkeys. For trichomoniasis in pigeons.