473. α-Aminopyridine

Nomenclature

CAS number: 504-29-0
2-Pyridinamine; 2-aminopyridine.
C5H6N2; mol wt 94.11.
C 63.81%, H 6.43%, N 29.77%.

Description and references

Prepd from pyridine and sodamide: Tschitschibabin, Chem. Zentralbl. 1915, I, 1065; Wibaut, Rec. Trav. Chim. 42, 240 (1923); A. I. Vogel, Practical Organic Chemistry (Longmans, London, 3rd ed., 1959) p 1007; Gattermann-Wieland, Praxis des Organischen Chemikers (de Gruyter, Berlin, 40th ed., 1961) p 316.

Chemical structure

Properties

Leaflets, or large crystals. mp 58.1°. bp 210.6°. Soluble in water, alcohol, benzene, ether, hot petrol ether.

Derivative

β-Aminopyridine.

Nomenclature

CAS number: 462-08-8
3-Pyridinamine.

Description and references

Prepn: Allen, Wolf, Org. Synth. coll. vol. IV, 45 (1963).

Properties

Crystals, mp 64°. bp 250-252°. Sol in water, alcohol, benzene, ether. Insol in petr ether.

Caution

Potential symptoms of overexposure to α-aminopyridine are irritation of eyes, nose, throat; headache, dizziness; excitement; nausea; high blood pressure; respiratory distress; weakness; convulsions; stupor. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 14.

Use

Manuf pharmaceuticals and dyes.