560. Ammonium Tetrathiomolybdate

Nomenclature

CAS number: 15060-55-6
(T-4)-Tetrathioxomolybdate(2) ammonium (1:2).
H8MoN2S4; mol wt 260.28.
H 3.10%, Mo 36.86%, N 10.76%, S 49.28%.
(NH4)2MoS4.

Description and references

Forms a complex with copper in vivo, blocking intestinal absorption. Prepn: G. Krüss, Ann. 225, 1 (1884); and characterization: J. W. McDonald et al., Inorg. Chim. Acta 72, 205 (1983). Thermal decomposition study: R. I. Walton et al., Chem. Mater. 10, 3737 (1998). Mechanism of action study: G. N. George et al., J. Am. Chem. Soc. 125, 1704 (2003). Use in treatment of copper poisoning in sheep: W. R. Humphries et al., Vet. Rec. 123, 51 (1988). Clinical evaluation in Wilson's disease: G. J. Brewer et al., Arch. Neurol. 51, 545 (1994); 53, 1017 (1996); 60, 379 (2003). Review of therapeutic potential: G. J. Brewer, J. Cell. Mol. Med. 7, 11-20 (2003).

Properties

uv max (H2O): 241, 316, 467 nm (ε 24700, 16750, 11850).

Use

In prepn of molybdenum disulfide, q.v., and other transition metal sulfide clusters.

Therapeutic Category

Chelating agent (copper); Wilson's Disease treatment.

Therapeutic Category (Veterinary)

Antidote (copper poisoning).

Keywords

Wilson's Disease Treatment; Chelating Agent