583. Amphetaminil

Nomenclature

CAS number: 17590-01-1
α-[(1-Methyl-2-phenylethyl)amino]benzeneacetonitrile; N-(α-methylphenethyl)-2-phenylglycinonitrile; α-phenyl-α-(β-phenylisopropylamino)acetonitrile; α-phenyl-α-(1-methyl-2-phenyl)ethylaminoacetonitrile; α-phenyl-α-N-(1-phenylisopropyl)aminoacetonitrile; AN 1 (Krugmann); Aponeuron (Apogepha).
C17H18N2; mol wt 250.34.
C 81.56%, H 7.25%, N 11.19%.

Description and references

Prepd by reaction of dl-β-phenylisopropylamine with sodium cyanide and benzaldehyde or with α-phenyl-α-bromoacetonitrile: Klosa, DE 1112987 (1959), C.A. 56, 3409d (1962); idem, J. Prakt. Chem. 20, 275 (1963). Pharmacology: Dominok, Oelssner, Acta Biol. Med. Ger. 20, 625 (1968); Beyer et al., Dtsch. Apoth. Ztg. 111, 677, 680 (1971). Metabolic studies: Remberg et al., Arch. Toxicol. 29, 153 (1972). Chemistry: Beyrich et al., Pharmazie 27, 28 (1972); Gloeckl, Beyrich, ibid. 95.

Chemical structure

Properties

Crystals from ethanol-water, mp 85-87°.

Derivative

Hydrochloride.
C17H19ClN2; mol wt 286.80.
C 71.19%, H 6.68%, Cl 12.36%, N 9.77%.

Properties

Sinters at 100-104°, mp 134-136°.

Therapeutic Category

Psychotropic.

Keywords

CNS Stimulant