590. Amprolium

Nomenclature

CAS number: 121-25-5
1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-methylpyridinium chloride (1:1); 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-picolinium chloride; Corid (Merck & Co.).
C14H19ClN4; mol wt 278.78.
C 60.32%, H 6.87%, Cl 12.72%, N 20.10%.

Description and references

Prepn: Rogers et al., J. Am. Chem. Soc. 82, 2974 (1960); Rogers, Sarett, US 3020277 (1962 to Merck & Co.), see also US 3020200. Formulations as poultry feed: Rogers, Sarett, US 3065132 (1962 to Merck & Co.).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

Amprol (Merck & Co.).
C14H19ClN4.HCl; mol wt 315.24.
C 53.34%, H 6.39%, Cl 22.49%, N 17.77%.

Properties

Crystals from methanol + ethanol, dec 248-249°. Freely sol in water, methanol, 95% ethanol, dimethylformamide. Sparingly sol in abs ethanol. Practically insol in isopropanol, butanol, dioxane, acetone, ethyl acetate, acetonitrile, isooctane. pH of 10% aq soln 2.5-3.0.

Therapeutic Category (Veterinary)

Coccidiostat.