592. Amrinone

Nomenclature

CAS number: 60719-84-8
5-Amino-[3,4′-bipyridin]-6(1H)-one; 3-amino-5-(4-pyridinyl)-2(1H)-pyridinone; Win-40680; Cartonic (Yamanouchi); Inocor (Sanofi Winthrop); Vesistol (Inverni); Wincoram (Sanofi Winthrop).
C10H9N3O; mol wt 187.20.
C 64.16%, H 4.85%, N 22.45%, O 8.55%.

Description and references

Selective cAMP phosphodiesterase (PDE-3) inhibitor with positive inotropic and vasodilatory activity. Prepn: G. Y. Lesher, C. J. Opalka, US 4004012; US 4072746 (1977, 1978 both to Sterling). Clinical hemodynamic assessment: J. R. Benotti et al., N. Engl. J. Med. 21, 1373 (1978). Review of pharmacology and clinical efficacy: A. Ward et al., Drugs 26, 468 (1983); M. B. Bottorff et al., Pharmacotherapy 5, 227-237 (1985). Series of articles on pharmacology, mechanism of action and clinical experience: J. Cardiothorac. Anesth. 6, Suppl. 2, 1-57 (1989).

Chemical structure

Properties

Crystals from DMF, mp 294-297° (dec).

Therapeutic Category

Cardiotonic.

Keywords

Cardiotonic