754. Aprindine

Nomenclature

CAS number: 37640-71-4
N1-(2,3-Dihydro-1H-inden-2-yl)-N3,N3-diethyl-N1-phenyl-1,3-propanediamine; N,N-diethyl-N′-2-indanyl-N′-phenyl-1,3-propanediamine; N-[3-(diethylamino)propyl]-N-phenyl-2-indanamine; compd 99170; AC-1802; Lilly 99170.
C22H30N2; mol wt 322.49.
C 81.94%, H 9.38%, N 8.69%.

Description and references

Membrane-stabilizing agent. Prepn: P. M. Vanhoof, P. M. Clarebout, BE 760018; eidem, US 3923813 (1971, 1975 both to Christiaens). Toxicological study: A. Georges et al., Arzneim.-Forsch. 23, 519 (1973). Pharmacokinetics: T. Kobari et al., Eur. J. Clin. Pharmacol. 26, 129 (1984). HPLC determn in plasma: T. Kobari et al., J. Chromatogr. 278, 220 (1983). Clinical studies: D. P. Zipes et al., Am. J. Cardiol. 40, 586 (1977); P. J. Troup, D. P. Zipes, Am. Heart J. 97, 322 (1979). Reviews: P. Danilo, ibid. 119; I. Stoel, S. F. Hagemeijer, Eur. Heart J. 1, 147 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 33237-74-0
Compd 83846; Amidonal (PCR Arzneimittel); Aspenon (Mitsui); Fiboran (Christiaens); Ritmusin (Gebro).
C22H30N2.HCl; mol wt 358.95.
C 73.61%, H 8.70%, N 7.80%, Cl 9.88%.

Properties

Crystals from benzene, mp 120-121°.

Therapeutic Category

Antiarrhythmic (class I).

Keywords

Antiarrhythmic