892. Azacosterol

Nomenclature

CAS number: 313-05-3
(3β,17β)-17-[[3-(Dimethylamino)propyl]methylamino]androst-5-en-3-ol; N-methyl-N-[3-(dimethylamino)propyl]-17β-aminoandrost-5-en-3β-ol; 20,25-diazacholesterol; diazasterol.
C25H44N2O; mol wt 388.63.
C 77.26%, H 11.41%, N 7.21%, O 4.12%.

Description and references

Prepn: Counsell et al., J. Med. Pharm. Chem. 5, 1224 (1962); Counsell, Klimstra, US 3084156 (1963 to Searle).

Chemical structure

Properties

Crystals from acetone + methanol, mp 146-148°. [α]D 54.5°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 1249-84-9
SC-12937; Ornitrol (Avitrol).
C25H44N2O.2HCl; mol wt 461.55.
C 65.06%, H 10.05%, N 6.07%, O 3.47%, Cl 15.36%.

Properties

[α]D 32°.

Therapeutic Category (Veterinary)

Avian chemosterilant.