911. Azimilide

Nomenclature

CAS number: 149908-53-2
1-[[[5-(4-Chlorophenyl)-2-furanyl]methylene]amino]-3-[4-(4-methyl-1-piperazinyl)butyl]-2,4-imidazolidinedione.
C23H28ClN5O3; mol wt 457.95.
C 60.32%, H 6.16%, Cl 7.74%, N 15.29%, O 10.48%.

Description and references

Potassium channel blocker. Prepn: S. S. Pelosi et al., WO 9304061 (1993 to Procter & Gamble); C.-N. Yu et al., US 5462940 (1995 to Norwich Eaton). Clinical pharmacokinetics: A. Corey et al., J. Clin. Pharmacol. 37, 946 (1997). Clinical trial to improve post-infarct survival: A. J. Camm et al., Am. J. Cardiol. 81, Suppl. 6A, 35D (1998). Review of electrophysiologic properties and pharmacology: R. Karam et al., ibid. 40D-46D.

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 149888-94-8
NE-10064; Stedicor (Procter & Gamble).
C23H28ClN5O3.2HCl; mol wt 530.88.
C 52.04%, H 5.70%, Cl 20.03%, N 13.19%, O 9.04%.

Properties

Crystals from ethanol/water.

Therapeutic Category

Antiarrhythmic (class III).

Keywords

Antiarrhythmic; Potassium Channel Blocker