Nomenclature
CAS number: 55852-84-1
Bacitracin methylenebis[2-hydroxybenzoate] (salt); bacitracin methylenedisalicylic acid; BMD (Alpharma); Solu-Tracin (Alpharma).
Description and references
Prepn: Baron, US 2774712 (1956 to S. B. Penick & Co.). LC determn in animal feed: G. K. Webster, J. AOAC Int. 80, 732 (1997).
Efficacy as growth promotant: A. L. Izat et al., Poult. Sci. 69, 1787 (1990); M.
D. Sims et al., ibid. 83, 1148 (2004); in combination with narasin vs necrotic
enteritis: J. Brennan et al., ibid. 82, 360 (2003).
Properties
White to grayish-brown powder. Slightly disagreeable
odor. Somewhat less bitter than bacitracin. uv max (dil acetic acid): 318 nm, min: 280 nm. Solubility in water about 50 mg/ml. pH of satd aq soln 3.5 to
5.0. Sol in pyridine, ethanol, less sol to insol in acetone, ether,
chloroform, pentane, benzene. Sol in dil aq alkali at pH 6 and higher,
increasingly insol at pH 6 to 3.Derivative
Sodium salt.
Properties
Creamy-white powder. Sol in water. pH 2% aq
soln 9.5.Therapeutic Category (Veterinary)
Animal growth promotant; antibacterial.