936. Bacitracin Zinc

Nomenclature

CAS number: 1405-89-6
Zinc bacitracin; Albac (Alpharma); Baciferm (Roche).

Description and references

Prepn: H. S. Anker et al., J. Bacteriol. 55, 249 (1948). Review of properties and formulatory characteristics: H. M. Gross, Drug Cosmet. Ind. 75, 612 (1954); idem et al., J. Am. Pharm. Assoc. Sci. Ed. 45, 447 (1956). Solubility data: P. J. Weiss et al., Antibiot. Chemother. 7, 374 (1957). ELISA determn in animal feed: C. Williams et al., Analyst 119, 427 (1994). Field trials as performance enhancer in pigs: S. C. Kyriakis et al., Vet. Rec. 138, 489 (1996); in chickens: G. Huyghebaert, G. De Groote, Poult. Sci. 76, 849 (1997). Clinical trial in giardiasis: B. J. Andrews et al., Am. J. Trop. Med. Hyg. 52, 318 (1995); in prevention of wound infection: D. J. Dire et al., Acad. Emerg. Med. 2, 4 (1995).

Properties

Creamy powder contg 1-4% H2O. Less bitter and more stable than bacitracin. Soly at about 28° (mg/ml): water 5.1; methanol 6.55; ethanol 2.0; isopropanol 0.16; ethyl acetate 1.3; chloroform 0.01; petr ether 0.025.

Therapeutic Category

Antibacterial.

Therapeutic Category (Veterinary)

Antibacterial; growth promotant.

Keywords

Antibacterial (Antibiotics); Polypeptides