953. Bambuterol
Nomenclature
CAS number: 81732-65-2
Dimethylcarbamic acid 5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]-1,3-phenylene
ester; 1-[bis(3′,5′-N,N-dimethylcarbamoyloxy)phenyl]-2-N-tert-butylaminoethanol; (±)-5-[2-(tert-butylamino)-1-hydroxyethyl]-m-phenylene bis(dimethylcarbamate); terbutaline bisdimethylcarbamate. C18H29N3O5; mol wt 367.44.
C 58.84%, H 7.96%, N 11.44%, O 21.77%.
Description and references
Ester prodrug of the β2-adrenergic agonist terbutaline, q.v. Prepn: O. A. T. Olsson et al., EP 43807; eidem, US 4419364 (1982, 1983 both to AB Draco). Pharmacology: O. A. T. Olsson, L.-A. Svensson, Pharm. Res. 1984, 19. Review of pharmacology and metabolism: L.-A. Svensson, Acta Pharm. Suec. 24, 333 (1987). LC determn: O. Wannerberg, B. Persson, J. Chromatogr. 435, 199 (1988). Clinical evaluation in asthma: T. Sandstrm et al., Respiration 53, 31 (1988). Clinical comparison with terbutaline: G. Persson et al., Eur. Respir. J. 1, 223 (1988).
Derivative
Hydrochloride.Nomenclature
CAS number: 81732-46-9
KWD-2183; Bambec (AstraZeneca). C18H29N3O5.HCl; mol wt 403.90.
C 53.53%, H 7.49%, N 10.40%, O 19.81%, Cl 8.78%.
Therapeutic Category
Bronchodilator.
Keywords
β-Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives