955. Bamifylline

Nomenclature

CAS number: 2016-63-9
7-[2-[Ethyl(2-hydroxyethyl)amino]ethyl]-3,7-dihydro-1,3-dimethyl-8-(phenylmethyl)-1H-purine-2,6-dione; 8-benzyl-7-[2-[ethyl(2-hydroxyethyl)amino]ethyl]theophylline; 8-benzyl-7-[N-ethyl-N-(β-hydroxyethyl)aminoethyl]theophylline; benzetamophylline; bamiphylline; 8102 CB.
C20H27N5O3; mol wt 385.46.
C 62.32%, H 7.06%, N 18.17%, O 12.45%.

Description and references

Prepn: BE 602888 (1961 to Christiaens), C.A. 56, 5981c (1962). Pharmacology: Georges et al., Therapie 17, 211 (1962). Metabolism: Dodion et al., Arzneim.-Forsch. 19, 785 (1969). Toxicological studies: Georges et al., ibid. 18, 460 (1968).

Chemical structure

Properties

Crystals, mp 80-80.5°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 20684-06-4
AC-3810; BAX-2739Z; Briofil (Alfa); Trentadil (Evans).
C20H27N5O3.HCl; mol wt 421.92.
C 56.93%, H 6.69%, N 16.60%, O 11.38%, Cl 8.40%.

Properties

Crystals, mp 185-186°. LD50 in mice, rats (mg/kg): 246, 1139 orally; 89, 131 i.p.; 67, 65 i.v. (Georges).

Therapeutic Category

Bronchodilator.

Keywords

Bronchodilator; Xanthine Derivatives