1047. Benoxinate

Nomenclature

CAS number: 99-43-4
4-Amino-3-butoxybenzoic acid 2-(diethylamino)ethyl ester; 3-butoxy-4-aminobenzoic acid 2-(diethylamino)ethyl ester; 2-(diethylamino)ethyl 4-amino-3-n-butoxybenzoate; oxibuprokain; oxybuprocaine.
C17H28N2O3; mol wt 308.42.
C 66.20%, H 9.15%, N 9.08%, O 15.56%.

Description and references

Prepn: GB 654484 (1951 to Wander).

Chemical structure

Properties

bp2 215-218°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 5987-82-6
Conjuncain (Mann); Cebesine (Chauvin); Novesine (CIBA Vision); Benoxil (Santen); Lacrimin (Santen).
C17H28N2O3.HCl; mol wt 344.88.
C 59.20%, H 8.48%, N 8.12%, O 13.92%, Cl 10.28%.

Properties

Crystals, mp ≈155° (USP XVI, 1960), also reported as mp 157-160° (N.N.R. 1955). Very sol in water, chloroform; sol in alc. Practically insol in ether. pH of aq solns, 4.5-5.2.

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)