1048. Benperidol

Nomenclature

CAS number: 2062-84-2
1-[1-[4-(4-Fluorophenyl)-4-oxobutyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-[1-[3-(p-fluorobenzoyl)propyl]-4-piperidyl]-2-benzimidazolinone; 1-[1-[4-(p-fluorophenyl)-4-oxobutyl]piperidin-4-yl]-2-benzimidazolinone; benzperidol; McN-JR-4584; R-4584; Anquil (Janssen-Cilag); Frénactil (Janssen-Cilag); Glianimon (Bayer).
C22H24FN3O2; mol wt 381.44.
C 69.27%, H 6.34%, F 4.98%, N 11.02%, O 8.39%.

Description and references

Prepn: BE 626307 (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755.

Chemical structure

Properties

Solid, mp 170-171.8°.

Derivative

Hydrochloride hydrate.

Properties

Solid, mp 134-142°.

Therapeutic Category

Antipsychotic.

Keywords

Antipsychotic; Butyrophenones