1083. Benziodarone

Nomenclature

CAS number: 68-90-6
(2-Ethyl-3-benzofuranyl) (4-hydroxy-3,5-diiodophenyl) methanone; 2-ethyl-3-(3′,5′-diiodo-4′-hydroxybenzoyl)benzofuran; 2-ethyl-3-(3′,5′-diiodo-4′-hydroxybenzoyl)oxaindene; 2-ethyl-3-benzofuryl 3′,5′-diiodo-4′-hydroxyphenyl ketone; 2-ethyl-3-(3,5-diiodo-4-hydroxybenzoyl)coumarone; 2-ethyl-3-(4-hydroxy-3,5-diiodobenzoyl)benzofuran; 2329 Labaz; L-2329; Amplivix; Dilafurane.
C17H12I2O3; mol wt 518.08.
C 39.41%, H 2.33%, I 48.99%, O 9.26%.

Description and references

Description: Charlier, Acta Cardiol. Suppl. 7, 1-60 (1959). Synthesis: Beaudet, Henaux, BE 553621; GB 836272 (1957, 1960, both to Labaz); Buu-Hoi, Beaudet, US 3012042 (1961 to Soc. Belge Azote Prod. Chim. Marly). Clinical trial in hyperuricemia in renal transplant patients: F. Perez-Ruiz et al., Nephrol. Dial. Transplant. 18, 603 (2003).

Chemical structure

Properties

Yellowish powder, mp 167°. Soly in water at 25° about 0.2%, at 45° about 1.0%. Sol in chloroform, acetone.

Therapeutic Category

Uricosuric.

Keywords

Uricosuric