1084. Benznidazole

Nomenclature

CAS number: 22994-85-0
2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide; N-benzyl-2-nitroimidazole-1-acetamide; Ro-7-1051; Radanil (Roche).
C12H12N4O3; mol wt 260.25.
C 55.38%, H 4.65%, N 21.53%, O 18.44%.

Description and references

Prepn: GB 1138529; A. G. Beaman et al., US 3679698 (1966, 1972 both to Hoffmann-La Roche). In vitro effect on T. cruzi: S. Yoneda et al., Experientia 33, 1201 (1977) DOI PubMed. Pharmacokinetics: J. Raaflaub, W. H. Ziegler, Arzneim.-Forsch. 29, 1611 (1979). Mutagenicity study: C. E. Voogd et al., Mutat. Res. 66, 207 (1979) DOI PubMed. Clinical trial in Chagas disease: A. L. S. Sgambatti de Andrade et al., Lancet 348, 1407 (1996) DOI PubMed; R. Viotti et al., Ann. Intern. Med. 144, 724 (2006) DOI PubMed.

Chemical structure

Properties

Crystals from ethanol, mp 188.5-190°. uv max (ethanol): 313 nm (ε 7,600). Soly in water at 37°: 40 mg/100 ml.

Therapeutic Category

Antiprotozoal (Trypanosoma).

Keywords

Antiprotozoal (Trypanosoma)