1115. Benzoylpas

Nomenclature

CAS number: 13898-58-3
4-(Benzoylamino)-2-hydroxybenzoic acid; N-benzoyl-p-aminosalicylic acid; 4-benzamidosalicylic acid.
C14H11NO4; mol wt 257.24.
C 65.37%, H 4.31%, N 5.44%, O 24.88%.

Description and references

Prepn: Drain et al., J. Chem. Soc. 1949, 1498; GB 676363 (1952 to Wander). Prepn of sodium and calcium salts: Suddaby, Sumpter, GB 711163 (1954 to Herst).

Chemical structure

Properties

Crystals, mp 260-261°.

Derivative

Calcium salt pentahydrate.

Nomenclature

CAS number: 5631-00-5
Benzoylpas calcium; Therapas (Smith & Nephew).
C28H20CaN2O8.5H2O; mol wt 642.62.
C 52.33%, H 4.71%, Ca 6.24%, N 4.36%, O 32.37%.

Properties

White powder or crystals.

Derivative

Mixture of calcium salt with isoniazid.

Nomenclature

Iso-Benzacyl (Novartis).

Therapeutic Category

Antibacterial (tuberculostatic).

Keywords

Antibacterial (Tuberculostatic)