1159. Bermoprofen

Nomenclature

CAS number: 78499-27-1
10,11-Dihydro-α,8-dimethyl-11-oxodibenz[b,f]oxepin-2-acetic acid; 2-(8-methyl-10,11-dihydro-11-oxodibenz[b,f]oxepin-2-yl)propionic acid; AD-1590; AJ-1590; Dibenon (Dainippon).
C18H16O4; mol wt 296.32.
C 72.96%, H 5.44%, O 21.60%.

Description and references

Prostaglandin synthetase inhibitor. Prepn: H. Uno et al., EP 3893; eidem, US 4238620 (1979, 1980 both to Dainippon); Y. Nagai et al., J. Med. Chem. 25, 1065 (1982). Pharmacology: H. Nakamura et al., Arzneim.-Forsch. 33, 1555 (1983). Mechanism of action: K. Ishii et al., Yakugaku Zasshi 108, 1001 (1988), C.A. 110, 33462v (1989).

Chemical structure

Properties

Crystals from toluene, mp 128-129°. LD50 in mice, rats (mg/kg): 500, 147 orally (Nakamura).

Therapeutic Category

Anti-inflammatory; antipyretic.