1176. Besipirdine

Nomenclature

CAS number: 119257-34-0
N-Propyl-N-4-pyridinyl-1H-indol-1-amine; 1-(propyl-4-pyridylamino)indole.
C16H17N3; mol wt 251.33.
C 76.46%, H 6.82%, N 16.72%.

Description and references

Cholinomimetic agent with noradrenergic activity. Prepn: R. C. Effland, J. T. Klein, EP 287982 (1988 to Hoechst); idem et al., US 4970218 (1990 to Hoechst-Roussel); of hydrochloride: S. Kongsamut et al., US 5356910 (1994 to Hoechst-Roussel). HPLC determn in plasma: R. S. Hsu et al., J. Chromatogr. 572, 352 (1991). Mechanism of action study: C. P. Smith et al., Drug Dev. Res. 32, 13 (1994). Pharmacokinetics: J. W. Hubbard et al., J. Clin. Pharmacol. 35, 688 (1995).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 130953-69-4
HP-749.
C16H17N3.HCl; mol wt 287.79.
C 66.77%, H 6.30%, N 14.60%, Cl 12.32%.

Properties

Crystals from methanol, mp 212-214°.

Derivative

Maleate.

Nomenclature

CAS number: 119257-40-8
C16H17N3.C4H4O4; mol wt 367.40.
C 65.38%, H 5.76%, N 11.44%, O 17.42%.

Properties

Crystals from methanol/ether, mp 115-116°.

Therapeutic Category

Nootropic.

Keywords

Nootropic