1178. Betahistine
Nomenclature
CAS number: 5638-76-6
N-Methyl-2-pyridineethanamine; 2-[2-(methylamino)ethyl]pyridine; [2-(2-pyridyl)ethyl]methylamine. C8H12N2; mol wt 136.19.
C 70.55%, H 8.88%, N 20.57%.
Description and references
Prepn: L"offler, Ber. 37, 161 (1904); Walter et al., J. Am. Chem. Soc. 63, 2771 (1941).
Properties
Liquid. bp30 113-114°. Soluble in water, alcohol, ether, chloroform.Derivative
Dihydrochloride.Nomenclature
CAS number: 5579-84-0
Betaserc (Duphar); Serc (Unimed); Vasomotal (Philips-Duphar). C8H12N2.2HCl; mol wt 209.12.
C 45.95%, H 6.75%, N 13.40%, Cl 33.91%.
Properties
Crystals from alc, mp 148-149°.Derivative
Maleate.Nomenclature
Suzutolon (Tatsumi).C8H12N2.C4H4O4; mol wt 252.27.
C 57.13%, H 6.39%, N 11.10%, O 25.37%.
Derivative
Mesylate.Nomenclature
Medan (Kowa); Menitazine (Towa Yakuhin); Merislon (Eisai); Remark (Nippon Zoki); Tenyl (Nippon Kayaku).C8H12N2.CH3SO3H; mol wt 232.30.
C 46.53%, H 6.94%, N 12.06%, S 13.80%, O 20.66%.
Derivative
Dimesylate.Nomenclature
Aequamen (Promonta); Melopat (Medopharm); Ribrain (Yamanouchi).C8H12N2.(CH3SO3H)2; mol wt 328.41.
C 36.57%, H 6.14%, N 8.53%, S 19.53%, O 29.23%.
Therapeutic Category
Vasodilator.
Keywords
Vasodilator (Peripheral)