1192. Bevantolol

Nomenclature

CAS number: 59170-23-9
1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol; 1-[(3,4-dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol.
C20H27NO4; mol wt 345.43.
C 69.54%, H 7.88%, N 4.05%, O 18.53%.

Description and references

Cardioselective β1-adrenergic blocker. Prepn: BE 790165; A. Holmes, R. F. Meyer, US 3857891 (1973, 1974 both to Parke, Davis & Co.); M. L. Hoefle et al., J. Med. Chem. 18, 148 (1975). Pharmacology in animals: S. G. Hastings et al., Arch. Int. Pharmacodyn. Ther. 226, 81 (1977). Cardiovascular effects in animals: I. D. Dukes, E. M. Vaughan Williams, Br. J. Pharmacol. 84, 365 (1985). Cardioselectivity in asthmatic patients: C.-G. L"ofdahl et al., Pharmacotherapy 4, 205 (1984). GC determn in plasma: E. J. Randinitis et al., J. Chromatogr. 308, 345 (1984). Pharmacokinetics in humans: P. Vermeij, P. van Brummelen, Eur. J. Clin. Pharmacol. 30, 375 (1986). Comparative clinical trial with hydrochlorothiazide in hypertension: C. P. Lucas et al., Clin. Ther. 8, 49 (1985). Symposium on pharmacology and clinical efficacy: Am. J. Cardiol. 58, 1E-44E (1986).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 42864-78-8
CI-775; Ranestol (Parke-Davis); Sentiloc (Benzon); Vantol (Parke-Davis).
C20H27NO4.HCl; mol wt 381.89.
C 62.90%, H 7.39%, N 3.67%, O 16.76%, Cl 9.28%.

Properties

Crystals from acetonitrile, mp 137-138°.

Therapeutic Category

Antianginal; antihypertensive; antiarrhythmic.

Keywords

β-Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives