1194. Bexarotene

Nomenclature

CAS number: 153559-49-0
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic acid; SR-11247; LGD-1069; Targretin (Ligand).
C24H28O2; mol wt 348.48.
C 82.72%, H 8.10%, O 9.18%.

Description and references

Selective retinoid X receptor (RXR) agonist. Prepn: M. F. Boehm et al., WO 9321146 (1993 to Ligand Pharm.); M. L. Dawson et al., US 5466861 (1995 to SRI Int.; La Jolla Cancer Res. Found.); and structure-activity study: M. F. Boehm et al., J. Med. Chem. 37, 2930 (1994); M. I. Dawson et al., ibid. 38, 3368 (1995). Chemopreventive effect in rat mammary carcinoma: M. M. Gottardis et al., Cancer Res. 56, 5566 (1996). Effect on glucose homeostasis in exptl diabetes: R. Mukherjee et al., Nature 386, 407 (1997). Clinical pharmacokinetics and evaluation in advanced cancers: V. A. Miller et al., J. Clin. Oncol. 15, 790 (1997). Clinical evaluation in cutaneous T-cell lymphoma: D. Breneman et al., Arch. Dermatol. 138, 325 (2002).

Chemical structure

Properties

White solid from methylene chloride, mp 230-231° (Dawson, 1995); also reported as white crystals, mp 234° (Boehm, 1994). uv max (methanol): 264 nm (ε 16400).

Therapeutic Category

Antineoplastic.

Keywords

Antineoplastic; Retinoids and Analogs